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elranatamab will enhance the degree or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Elranatamab causes cytokine launch syndrome (CRS) which will suppress activity of CYP enzymes, causing elevated exposure of CYP substrates.fentanyl transdermal and mirtazapine both of those boost sedatio